Submit your skincare questions to Dr. Agnes, CEO of Herborium and natural medicine expert
Herborium has developed and will be introducing a new product line "The AcnEase Skin Management System?" (ASMS) the perfect compliment to AcnEase. ASMS will contain a line of products including: a mask containing colloidal gold for repairing acne marks and scars, a natural hypoallergenic line of topical products supporting healthy skin and a product addressing existing pimples.
AcnEase® is a
proprietary all natural botanical therapeutic® specifically
developed to treat skin disorders including acne. AcnEase is a blend of the
highest quality herbal extracts selected for their inherent properties to
overcome the medically recognized factors involved in the formation of
whiteheads, blackheads and pimples. This
clinically tested product provides a necessary balance between demonstrated
effectiveness and safety for individuals suffering from acne. AcnEase is gluten
free, phytoestrogens free, animal by products free and chemical and GMO free.
ingredients work synergistically to restore the internal physiologic balance
that is disrupted by endocrine changes, mental tension, stress and diet. Acne
is actually a visible or external manifestation of an internal disorder. Acne
is caused by an over production of sebum by the sebaceous glands in your
skin. This excess sebum tends to clog
pores, which then accumulate dead skin cells and bacteria. These clogged pores are visible on the
surface of the skin as white heads, black heads (comedones) and pimples.
AcnEase works to decrease this excess sebum production, thereby decreasing oily
skin, and reducing the number of comedones and pimples seen on the surface of
the skin. AcnEase is therefore unique in that it addresses the cause of acne
and skin related problems.
AcnEase has been shown in clinical trials to successfully (95%)
improve acne in patients 15-31 years of age caused by overproduction of the sex
hormones (androgens or estrogen) and to reduce the inflammation caused by
bacteria growing in the clogged pores of the skin. AcnEase has also been shown
to be a highly effective (over 85% response rates) for adults with chronic and
adult acne. This is not surprising since the same factors responsible for
teenage acne cause adult acne. Since
AcnEase was developed to correct, its beneficial effect is not restricted to acne.
Improvement in chronic facial flushing and GI related problems associated with
chronic facial flushing (Rosacea) and acne have also been reported following
AcnEase has received the
highest award for clinical efficacy in China, successfully improving acne in
more than 95% of patients in controlled clinical studies. Today AcnEase is
manufactured in the USA under current Good Manufacturing Practices (GMPs),
satisfying the highest standards for manufacturing of herbal-based medicines. Experiential data collected from thousands of
customers indicates over a 96% satisfaction rate.
Depending on the
severity of the symptoms, AcnEase may produce noticeable results within 1-2
weeks. To achieve general improvement in cysts, whiteheads, blackheads, or
pimples, the standard 1 month of treatment must be completed. For individuals
whose acne is chronic, and was resistant to standard Western medical treatment,
an increased dose and duration may be necessary. Learn which treatment is
right for you based upon your symptoms.
The ingredients present
in AcnEase have been tested extensively at doses that greatly exceed the human
dose, and have been shown to be safe with no signs of toxicity (Preclinical Safety). In addition, none of
the herbal ingredients present in the AcnEase formula have been cited on the
list of dangerous herbs compiled by International regulatory authorities; nor is
it on their list of herbs known to cause serious side effects. The herbs used
to make AcnEase are not present on the endangered species list either.
AcnEase achieves its
beneficial effects by targeting the cause of acne without the harmful effects
associated with the long-term use of other systemic agents. Oral antibiotics for instance are taken to
reduce the number of bacteria growing in clogged pores; they do not prevent
over production of sebum. The widespread
use of antibiotics is not supported by the medical community due to the
development of antibiotic resistant bacteria. Isotretinoins (Accutane) do
target over secretion by sebaceous glands, but are associated with a number of
serious side effects including depression in young males, birth defects,
inflammatory bowel disease etc. Accutane is actually presently a subject of
Class Action Suit in regards to those adverse effects and the use of its generic versions is
reserved for the most severe forms of chronic acne and accompany by a legal
For mild to moderate
acne, topical agents are routinely used.
Firstly, these products primarily treat existing pimples and do little
to prevent new pimples from forming. The most common active ingredients present
in topical products include benzoyl peroxide ) and salicylic acid; both
ingredients can lead to dry, irritated and prematurely aged skin. Many topical products, including the retinoic
acid based products, cause skin irritation and also have sun restrictions for
use. The common denominator for all topical products is they all treat the
visible manifestation of acne, “the pimple” but do little to prevent future
acne. AcnEase is unique in that it targets
the cause of acne providing longer-term results. And given its unique mechanism of action, it
can be used carefully in conjunction with topical agents.
Below please find a comparison between AcnEase® and other acne products
Information derived from the 2010 Physicians Desk Reference. Revised by Herborium Group, Inc., 2011.
1 Accutane has been reported to cause severe depression especially in young men
2 Products in categories C and B relating to pregnancy should only be used after consulting your physician
AcnEase® has also been shown to be effective in older individuals with Chronic Acne, however, the response rate in these studies was lower. Since AcnEase® was developed to correct bodily imbalance its beneficial effect is not restricted to Acne. Improvement in chronic facial flushing and GI related problems associated with chronic facial flushing and Acne have also been reported following treatment.
Clinical Experience * AcnEase®
* Data summarized from Chinese NDA submission.
* * Responders are those that improved but did not show a complete recovery at the end of the first course of therapy.
*** %Effective is equal to the total number of patients cured and responders.
These results demonstrate that in adolescent Acne approximately 95% of the patients responded to AcnEase®. In people above 31 years of age the level of effectiveness dropped slightly to 80%. The overall positive response rate to AcnEase® treatment was therefore 91%.
Safety assessment was based upon physical
examinations, abdominal ultrasound, EKG, thoracic X-ray and full clinical
chemistry and hematology. Any possible adverse
events or side effects were also monitored.
All clinical chemistry and hematology tests
following 30 days of treatment were found to be normal. All physical examinations, including
abdominal ultrasound, EKG’s and X-Rays were found to be in normal in all ranges
following treatment. There was no sign
of allergic responses or any form of anaphylactic response.
Four distinct studies were performed
including: a maximal tolerated dose/LD50 experiment in mice, bone
marrow micro-nucleus assay for mutagenicity, Ames test, and the mouse sperm
cell deformity assay. In the study on mice the used dose represented
approximately 24 to 240 times the standard human dose used in AcnEase. The mice
were observed for 2 weeks for all signs and symptoms of toxicity. There
were no overt signs of toxicity and no recorded deaths determined for both males
use of the Ames test is a standard method used to explore the mutagenic
potential of test articles. The experiments are performed on the active
ingredients directly and in a second test following incubation with mircrosomal
enzymes. The drugs are incubated with
the liver microsomes to mimic the effect of liver metabolism on the active
ingredients to insure that metabolites of the drug do not possess mutagenic
potential. The test is performed in 4
separate bacterial strains.
results clearly demonstrated that AcnEase is not mutagenic in the Ames Assay
when tested directly or following incubation with mircrosomal enzymes.
purpose of these experiments is to determine if AcnEase will induce chromosomal
aberrations, which is an index of mutagenicity and carcinogenicity. 50 Kunming mice (25 males and 25 females)
weighing between 35-30 grams were used in this study. The results clearly demonstrated that AcnEase® treatment does not induce changes in bone marrow chromosomes supporting the position that the product is not likely to induce mutagenic are carcinogenic changes in cells.
assay is performed to determine if AcnEase will induce aberrations in germ cell
lines. The xxperiments were performed in
25 male Kunming
mice 25-35 grams in weight. The
results demonstrated no statistically significant difference between the
control group and any of the AcnEase tested
groups. The results confirmed that AcnEase
does not adversely affect germ cell lines.
The AcnEase® formula is protected by trade secrets and the product is manufactured in the USA in an FDA approved facility.
AcnEase® is manufactured in the USA according to GMPs (Good Manufacturing Practices). The herbs are tested extensively (see QC) before being extracted using state of the art equipment. Extracts are boiled for 1 hour 40 minutes; raw materials that are not extracted are hot air sterilized at 140°C for 3 hours. The finished products are then thin coated to minimize taste and facilitate swallowing, and packaged in temper and environment resistant bottles.
All raw materials and final tablets are subjected to rigorous testing according to pharmacopeia`s standards.
Raw materials are visually inspected for evidence of mold, rot or any indication that the herbs are not of acceptable quality according to specific SOP's. Each extract is tested for: DDT, Benzex, Arsenic, and Lead. Microbiological testing is performed to check for Colony Forming Units, colibacillus, serratieae, shigella, golden staphylococcus, hemolytic staphylococcus, pathogenic bacteria, mold and yeast.
Tablets are routinely tested according to a predetermined regimen as to meet the quality standards regarding purity and stability of the ingredients and water content. The tablets are also tested for hardness, appearance, integrity and dissolution. Stability testing for a minimum of 24 months is also performed on the commercial batches.